Genetic variants associated with protein C levels
نویسندگان
چکیده
منابع مشابه
Multidrug resistance-associated protein-1 (MRP1) genetic variants, MRP1 protein levels and severity of COPD
BACKGROUND Multidrug resistance-associated protein-1 (MRP1) protects against oxidative stress and toxic compounds generated by cigarette smoking, which is the main risk factor for chronic obstructive pulmonary disease (COPD). We have previously shown that single nucleotide polymorphisms (SNPs) in MRP1 significantly associate with level of FEV1 in two independent population based cohorts. The ai...
متن کاملAre C-Reactive Protein Associated Genetic Variants Associated with Serum Levels and Retinal Markers of Microvascular Pathology in Asian Populations from Singapore?
INTRODUCTION C-reactive protein (CRP) levels are associated with cardiovascular disease and systemic inflammation. We assessed whether CRP-associated loci were associated with serum CRP and retinal markers of microvascular disease, in Asian populations. METHODS Genome-wide association analysis (GWAS) for serum CRP was performed in East-Asian Chinese (N = 2,434) and Malays (N = 2,542) and Sout...
متن کاملIdentification of Genetic Variants Linking Protein C and Lipoprotein Metabolism
Protein C is a vitamin K–dependent glycoprotein produced by the liver that circulates in plasma as a zymogen. Once activated by the thrombin–thrombomodulin complex, protein C is a multifunctional molecule with anticoagulant, anti-inflammatory, antiapoptotic, and cytoprotective properties. Activated protein C inactivates factor V a and factor VIII a , thereby reducing the generation of thrombin....
متن کاملGenetic Variants Associated with Colorectal Adenoma Susceptibility
BACKGROUND Common low-penetrance genetic variants have been consistently associated with colorectal cancer risk. AIM To determine if these genetic variants are associated also with adenoma susceptibility and may improve selection of patients with increased risk for advanced adenomas and/or multiplicity (≥ 3 adenomas). METHODS We selected 1,326 patients with increased risk for advanced adeno...
متن کاملGenetic variants associated with sleep disorders
OBJECTIVE The diagnostic boundaries of sleep disorders are under considerable debate. The main sleep disorders are partly heritable; therefore, defining heritable pathophysiologic mechanisms could delineate diagnoses and suggest treatment. We collected clinical data and DNA from consenting patients scheduled to undergo clinical polysomnograms, to expand our understanding of the polymorphisms as...
متن کاملذخیره در منابع من
با ذخیره ی این منبع در منابع من، دسترسی به آن را برای استفاده های بعدی آسان تر کنید
ژورنال
عنوان ژورنال: Journal of Thrombosis and Haemostasis
سال: 2013
ISSN: 1538-7933
DOI: 10.1111/jth.12157